Polynucleotides contain fragments of DNA and are administered via multiple small injections. According to dermatologist Dr Elif Benar, they “promote cell turnover, enhance tissue repair, and stimulate the production of collagen and elastin, leading to improved skin texture and elasticity.” It’s worth mentioning that the quality of polynucleotides is essential to their success. When I decided to see if they would make the skin on my chest less weather-beaten (they did), I opted for DermaFocus Plinest, which is the UK’s first CE certified brand. Aim for two to three sessions, with maintenance every six to 12 months.
SKIN
- Noticeably reduces the appearance of age related pigment
- Visibly makes skin appear firmer and more youthful
- Visibly reduces the appearance of fine lines and wrinkles
- Hydrates and nourishes skin
- Promotes a more radiant and even toned complexion
These gained prominence this year for their ability to repair and regenerate skin. Plastic surgeon Dr Sofiane Rimouche explains they “are signaling messengers from stem cells and have a whole host of potential benefits and applications”, meaning they are ideal if you want to reduce inflammation and improve skin condition. You’ll likely need three to five sessions for the full results, with top-ups every six months to a year.
Rejuran Healer is a skin healing treatment that has surged in popularity over the last few months. The world cannot seem get enough of skin rejuvenating injection treatments. Skinboosters was the must-have treatment last year, but today, Rejuran Healer, from South Korea has become the treatment on everyone’s lips and minds. Rejuran is also commonly referred to as Rejuran Healer, PN, PDRN Therapy, Miracle Healer Injection, or 婴儿针 (Baby skin injections).
What is Rejuran Healer Treatment?
Rejuran Healer is a rejuvenating skin treatment made of biological molecules called polynucleotides (PN). A PN molecule is a biopolymer made up of 13 or more nucleotide monomers bonded together. If nucleotides sound familiar, it is because you probably heard about it in biology class – nucleotides are the basic structural units which make up DNA!
The DNA extract in Rejuran Healer is obtained from salmon, then fragmented into PNs.
How Does Rejuran Healer Treatment Work?
The 2 main effects of Rejuran Healer, or PN/PDRN are:
- Wound healing – through stimulation of growth factors, increased microcirculation,
- Anti-inflammatory effects – through scavenging of free radicals and blockage of inflammatory cytokines in the body.
Rejuran does this through several mechanisms:
- PN/PDRN work by biologically increasing the metabolic activity of cells in the skin called fibroblasts – the fibroblasts in the skin are stimulated to regenerate key components of the skin which we lose with age, such as collagen, glycosaminoglycans and glycoproteins. In other words, PNs awaken tired aged cells to act younger and get to work again.
- PN/PDRN act mechanically as a scaffolding for cells and the extracellular matrix to grow – they have a 3-dimensional structure where fibroblasts can use to produce its regenerative effects.
- PN/PDRN provide building blocks for DNA synthesis. Through salvage pathways, the PNs are broken down by the body’s processes into purines and pyrimidines, then recycled into new DNA again.
Why is Salmon DNA Used for Skin Rejuvenation?
A study was published in March 2010 to investigate the effect of rubbing salmon DNA on human skin6. The results were surprising – just by doing that, subjects showed a significant improvement in skin elasticity, texture and hydration.
Salmon DNA is used in Rejuran as it is very similar to human DNA. Researchers also found that salmon DNA is very safe and compatible in the human body without causing any adverse side effects. The salmon DNA used in Rejuran is purified to be free from other components such as proteins which may trigger an immune response.
What Benefits Does Rejuran Healer Have?
Rejuran PN/PDRN’s healing properties have several beneficial effects on the skin, as shown in their funded study7:
- Improved skin elasticity
- Improved Hydration
- Reduced fine lines and wrinkles
- Skin repair – with improved skin barrier function
- Skin normalization – thickening of skin, regulation of oil production
- Improved skin tone
- Improved skin texture
Benefits of PDRN
Let’s start with all the benefits that polydeoxyribonucleotides have when it comes to incorporating it into your skincare routine:
- Rejuvenating – Salmon DNA regenerates tissues by activating the microvessels in your skin and activating fibroblasts to help boost collagen production.
- Repairing – It repairs even deep layers of skin damage, improves skin elasticity, and strengthens the skin's natural barrier to prevent further damage.
- Tissue Regeneration – Skin regenerates naturally, but this speeds up the process for long-lasting healthy, radiant skin.
- Stimulating – It stimulates elastin production and collagen growth in the skin.
- Tones – Dark spots and discoloration are smoothed for a brighter and more even skin tone.
- Anti-inflammatory – It works at the cellular level to decrease inflammation in your face and skin, promoting healing and cutting down on the amount of puffiness you might experience.
- Biocompatible – As a naturally occurring ingredient, PDRN has excellent biocompatibility with human skin, making adverse reactions rare.
Its two main functions, repairing and regenerating, have propelled PDRN forward in skincare routines across the globe. It improves skin quality and prepares the skin to respond to other treatments, serums, and skincare products.
Skin Regeneration and Wound Healing
Skin regeneration is vital to keeping happy and healthy skin in our faces, but it’s also essential to healing wounds; this is another area where PDRN shines. Recent studies have found that it has proven encouraging results in terms of healing time, wound regeneration, and absence of side effects. It’s even been effective in situations where wound healing is impaired, like diabetes, severe burns, and lack of blood flow.
These findings have brought polydeoxyribonucleotides to the front and center of the skincare scene, and the best news is that you don’t have to go to a doctor to reap the benefits. There are methods of using these skin regenerating treatments right in your home.
PDRN Applications
While everyone’s skin can benefit from polydeoxyribonucleotides, it’s best for individuals who have experienced slow healing, dark spots or lesions on their faces, and post-acne hyperpigmentation. It’s also highly applicable to those who deal with early-onset aging signs like loss of skin density, dull and dry skin, deep wrinkles, age spots, and fine lines.
There are several different methods of getting PDRN into the skin, and they can all be highly effective methods of boosting skin regeneration. You can get all the benefits of the ingredient in any of the following ways:
- Topical Serums – One of the easiest ways to start incorporating this ingredient into your skincare routine is through a topical serum. It can be gently massaged into the skin and allowed to sit for several minutes for maximum absorption. You can apply these serums during facials and other skincare treatments.
- Masks – Facial masks containing polydeoxyribonucleotides are becoming popular as an easy and non-invasive way to get the skin regenerating ingredient into your skin. Most of these masks are recommended one to three times per week and can even be used every day for some skin types. Repairing masks often contain other active ingredients like sodium hyaluronate and spirulina platensis extract to aid tissue regeneration and skin hydration.
Fight Aging at the Cellular Level
It’s amazing to think about the effects those tiny little molecules derived from salmon DNA can have on our skin. Its unique ability to penetrate our skin to its deepest level and repair damaged DNA is remarkable. It’s like a real-life fountain of youth.
It’s never too late to take care of your skin. And even if you think your wrinkles and sunspots are too far gone, think again. PDRN works to repair your skin from within so that you can experience a reduced appearance of scars, wrinkles, and stretch marks. Treatments can also minimize pore size, boost new cell growth, improve skin elasticity, and help with your skin’s hydration levels.
Read and Watch the video on PDRN!
Polynucleotides
Polynucleotides contain fragments of DNA and are administered via multiple small injections. According to dermatologist Dr Elif Benar, they “promote cell turnover, enhance tissue repair, and stimulate the production of collagen and elastin, leading to improved skin texture and elasticity.” It’s worth mentioning that the quality of polynucleotides is essential to their success. When I decided to see if they would make the skin on my chest less weather-beaten (they did), I opted for DermaFocus Plinest, which is the UK’s first CE certified brand. Aim for two to three sessions, with maintenance every six to 12 months.